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Cryo-EM structures and functional characterization of homo- and heteropolymers of human ferritin variants

The role of abnormal brain iron metabolism in neurodegenerative diseases is still insufficiently understood. Here, we investigate the molecular basis of the neurodegenerative disease hereditary ferritinopathy (HF), in which dysregulation of brain iron homeostasis is the primary cause of neurodegener...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Irimia-Dominguez, Jose, Sun, Chen, Li, Kunpeng, Muhoberac, Barry B., Hallinan, Grace I., Garringer, Holly J., Ghetti, Bernardino, Jiang, Wen, Vidal, Ruben
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7692541/
https://ncbi.nlm.nih.gov/pubmed/33244127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77717-4
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