Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia

BACKGROUND: Sickle cell disease (SCD) is a severe and devastating hematological disorder that affects over 100,000 persons in the USA and millions worldwide. Hydroxyurea is the primary disease-modifying therapy for the SCD, with proven benefits to reduce both short-term and long-term complications....

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Detalhes bibliográficos
Publicado no:Trials
Main Authors: Meier, Emily R., Creary, Susan E., Heeney, Matthew M., Dong, Min, Appiah-Kubi, Abena O., Nelson, Stephen C., Niss, Omar, Piccone, Connie, Quarmyne, Maa-Ohui, Quinn, Charles T., Saving, Kay L., Scott, John P., Talati, Ravi, Latham, Teresa S., Pfeiffer, Amanda, Shook, Lisa M., Vinks, Alexander A., Lane, Adam, McGann, Patrick T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691962/
https://ncbi.nlm.nih.gov/pubmed/33246482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-020-04912-z
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