Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking

The hyperpolarization-activated cation current I(f) is a key determinant for cardiac pacemaker activity. It is conducted by subunits of the hyperpolarization-activated cyclic nucleotide–gated (HCN) channel family, of which HCN4 is predominant in mammalian heart. Both loss-of-function and gain-of-fun...

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Detalhes bibliográficos
Publicado no:Pflugers Arch
Main Authors: Erlenhardt, Nadine, Kletke, Olaf, Wohlfarth, Franziska, Komadowski, Marlene A., Clasen, Lukas, Makimoto, Hisaki, Rinné, Susanne, Kelm, Malte, Jungen, Christiane, Decher, Niels, Meyer, Christian, Klöcker, Nikolaj
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Ion Channels, Receptors and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691308/
https://ncbi.nlm.nih.gov/pubmed/33095298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-020-02481-3
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