Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

Hematopoietic stem cells (HSCs) exhibit functional alterations, such as reduced regenerative capacity and myeloid-biased differentiation, with age. The HSC niche, which is essential for the maintenance of HSCs, also undergoes marked changes with aging. However, it has been technically challenging to...

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Bibliographische Detailangaben
Veröffentlicht in:J Exp Med
Hauptverfasser: Kuribayashi, Wakako, Oshima, Motohiko, Itokawa, Naoki, Koide, Shuhei, Nakajima-Takagi, Yaeko, Yamashita, Masayuki, Yamazaki, Satoshi, Rahmutulla, Bahityar, Miura, Fumihito, Ito, Takashi, Kaneda, Atsushi, Iwama, Atsushi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2020
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7690939/
https://ncbi.nlm.nih.gov/pubmed/33231616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20192283
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