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Rac1 inhibition via Srgap2 restrains inflammatory osteoclastogenesis and limits the clastokine, SLIT3
The Rac1-specific GTPase activating protein Slit-Robo GAP2 (Srgap2) is dramatically up regulated during RANKL-induced osteoclastogenesis. Srgap2 interacts with the cell membrane to locally inhibit activity of Rac1. In this study, we determined the role of Srgap2 in the myeloid lineage on bone homeos...
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| Publicat a: | J Bone Miner Res |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7690287/ https://ncbi.nlm.nih.gov/pubmed/31880824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3945 |
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