Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma and a hypoxic microenvironment. Pancreatic stellate cells (PSC) are activated by hypoxia and promote excessive desmoplasia, further contributing to the development of hypoxia. We aimed to explore how hypoxia and stroma inter...

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Udgivet i:Biomedicines
Main Authors: Liu, Dajia, Steins, Anne, Klaassen, Remy, van der Zalm, Amber P., Bennink, Roel J., van Tienhoven, Geertjan, Besselink, Marc G., Bijlsma, Maarten F., van Laarhoven, Hanneke W. M.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7690284/
https://ncbi.nlm.nih.gov/pubmed/33105540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines8110444
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