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First Ring‐Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant
A multiblocked mutant strain (ΔAHBA and Δasm12, asm21) of Actinosynnema pretiosum, the producer of the highly toxic maytansinoid ansamitocin, has been used for the mutasynthetic production of new proansamitocin derivatives. The use of mutant strains that are blocked in the biosynthesis of an early b...
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| Izdano u: | Chembiochem |
|---|---|
| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7689855/ https://ncbi.nlm.nih.gov/pubmed/32484951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000336 |
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