Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin

Heterologous expression of a biosynthesis gene cluster from Amycolatopsis sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of cancer cells, while having no such effect on the normal cells. Detailed investiga...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:iScience
Autores principales: Guerrero-Garzón, Jaime Felipe, Madland, Eva, Zehl, Martin, Singh, Madhurendra, Rezaei, Shiva, Aachmann, Finn L., Courtade, Gaston, Urban, Ernst, Rückert, Christian, Busche, Tobias, Kalinowski, Jörn, Cao, Yan-Ru, Jiang, Yi, Jiang, Cheng-lin, Selivanova, Galina, Zotchev, Sergey B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689547/
https://ncbi.nlm.nih.gov/pubmed/33294793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101785
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares