Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin

Heterologous expression of a biosynthesis gene cluster from Amycolatopsis sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of cancer cells, while having no such effect on the normal cells. Detailed investiga...

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Publicado no:iScience
Main Authors: Guerrero-Garzón, Jaime Felipe, Madland, Eva, Zehl, Martin, Singh, Madhurendra, Rezaei, Shiva, Aachmann, Finn L., Courtade, Gaston, Urban, Ernst, Rückert, Christian, Busche, Tobias, Kalinowski, Jörn, Cao, Yan-Ru, Jiang, Yi, Jiang, Cheng-lin, Selivanova, Galina, Zotchev, Sergey B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689547/
https://ncbi.nlm.nih.gov/pubmed/33294793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101785
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