Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling

Tyrosine kinase A (TrkA) is a membrane receptor which, upon ligand binding, activates several pathways including MAPK/ERK signaling, implicated in a spectrum of human pathologies; thus, TrkA is an emerging therapeutic target in treatment of neuronal diseases and cancer. However, mechanistic insights...

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Publicat a:Commun Biol
Autors principals: Zhao, Shu, Shi, Jia, Yu, Guohua, Li, Dali, Wang, Meng, Yuan, Chonggang, Zhou, Huihui, Parizadeh, Amirabbas, Li, Zhenlin, Guan, Min-Xin, Ye, Shixin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689462/
https://ncbi.nlm.nih.gov/pubmed/33239753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01396-0
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