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Assembly of the [4Fe–4S] cluster of NFU1 requires the coordinated donation of two [2Fe–2S] clusters from the scaffold proteins, ISCU2 and ISCA1
NFU1, a late-acting iron–sulfur (Fe–S) cluster carrier protein, has a key role in the pathogenesis of the disease, multiple mitochondrial dysfunctions syndrome. In this work, using genetic and biochemical approaches, we identified the initial scaffold protein, mitochondrial ISCU (ISCU2) and the seco...
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| Pubblicato in: | Hum Mol Genet |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7689295/ https://ncbi.nlm.nih.gov/pubmed/32776106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa172 |
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