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Mitochondrial [4Fe-4S] protein assembly involves reductive [2Fe-2S] cluster fusion on ISCA1–ISCA2 by electron flow from ferredoxin FDX2

The essential process of iron-sulfur (Fe/S) cluster assembly (ISC) in mitochondria occurs in three major phases. First, [2Fe-2S] clusters are synthesized on the scaffold protein ISCU2; second, these clusters are transferred to the monothiol glutaredoxin GLRX5 by an Hsp70 system followed by insertion...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Weiler, Benjamin Dennis, Brück, Marie-Christin, Kothe, Isabell, Bill, Eckhard, Lill, Roland, Mühlenhoff, Ulrich
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456137/
https://ncbi.nlm.nih.gov/pubmed/32817474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003982117
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