CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300 mutated lymphomas

Somatic mutations affecting CREBBP and EP300 are a hallmark of Diffuse Large B Cell Lymphoma (DLBCL). These mutations are frequently monoallelic, within the histone acetyltransferase (HAT) domain and usually mutually exclusive, suggesting that they might affect a common pathway and their residual WT...

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Gepubliceerd in:Leukemia
Hoofdauteurs: Veazey, Kylee J., Cheng, Donghang, Lin, Kevin, Villarreal, Oscar D., Gao, Guozhen, Perez-Oquendo, Mabel, Van, Hieu T., Stratton, Sabrina A., Green, Michael, Xu, Han, Lu, Yue, Bedford, Mark T., Santos, Margarida Almeida
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688486/
https://ncbi.nlm.nih.gov/pubmed/32576962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0908-8
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