Human‐engineered Treg‐like cells suppress FOXP3‐deficient T cells but preserve adaptive immune responses in vivo

OBJECTIVES: Genetic or acquired defects in FOXP3(+) regulatory T cells (Tregs) play a key role in many immune‐mediated diseases including immune dysregulation polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome. Previously, we demonstrated CD4(+) T cells from healthy donors and IPEX patients c...

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Detalhes bibliográficos
Publicado no:Clin Transl Immunology
Main Authors: Sato, Yohei, Passerini, Laura, Piening, Brian D, Uyeda, Molly Javier, Goodwin, Marianne, Gregori, Silvia, Snyder, Michael P, Bertaina, Alice, Roncarolo, Maria‐Grazia, Bacchetta, Rosa
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688376/
https://ncbi.nlm.nih.gov/pubmed/33304583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cti2.1214
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