IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages

Metabolic traits of macrophages can be rewired by insulin-like growth factor 2 (IGF2); however, how IGF2 modulates macrophage cellular dynamics and functionality remains unclear. We demonstrate that IGF2 exhibits dual and opposing roles in controlling inflammatory phenotypes in macrophages by regula...

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Dades bibliogràfiques
Publicat a:Sci Adv
Autors principals: Wang, Xuefeng, Lin, Liangyu, Lan, Bin, Wang, Yu, Du, Liming, Chen, Xiaodong, Li, Qing, Liu, Keli, Hu, Mingyuan, Xue, Yueqing, Roberts, Arthur I., Shao, Changshun, Melino, Gerry, Shi, Yufang, Wang, Ying
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688333/
https://ncbi.nlm.nih.gov/pubmed/33239287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb7389
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