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Snx3 is important for mammalian neural tube closure via its role in canonical and non-canonical WNT signaling

Disruptions in neural tube (NT) closure result in neural tube defects (NTDs). To understand the molecular processes required for mammalian NT closure, we investigated the role of Snx3, a sorting nexin gene. Snx3(−/−) mutant mouse embryos display a fully-penetrant cranial NTD. In vivo, we observed de...

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Podrobná bibliografie
Vydáno v:Development
Hlavní autoři: Brown, Heather Mary, Murray, Stephen A., Northrup, Hope, Au, Kit Sing, Niswander, Lee A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687862/
https://ncbi.nlm.nih.gov/pubmed/33214242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.192518
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