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Snx3 is important for mammalian neural tube closure via its role in canonical and non-canonical WNT signaling

Disruptions in neural tube (NT) closure result in neural tube defects (NTDs). To understand the molecular processes required for mammalian NT closure, we investigated the role of Snx3, a sorting nexin gene. Snx3(−/−) mutant mouse embryos display a fully-penetrant cranial NTD. In vivo, we observed de...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Brown, Heather Mary, Murray, Stephen A., Northrup, Hope, Au, Kit Sing, Niswander, Lee A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687862/
https://ncbi.nlm.nih.gov/pubmed/33214242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.192518
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