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Snx3 is important for mammalian neural tube closure via its role in canonical and non-canonical WNT signaling
Disruptions in neural tube (NT) closure result in neural tube defects (NTDs). To understand the molecular processes required for mammalian NT closure, we investigated the role of Snx3, a sorting nexin gene. Snx3(−/−) mutant mouse embryos display a fully-penetrant cranial NTD. In vivo, we observed de...
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| Publicado no: | Development |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7687862/ https://ncbi.nlm.nih.gov/pubmed/33214242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.192518 |
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