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Target‐Directed Azide‐Alkyne Cycloaddition for Assembling HIV‐1 TAR RNA Binding Ligands

The highly conserved HIV‐1 transactivation response element (TAR) binds to the trans‐activator protein Tat and facilitates viral replication in its latent state. The inhibition of Tat–TAR interactions by selectively targeting TAR RNA has been used as a strategy to develop potent antiviral agents. Th...

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Библиографические подробности
Опубликовано в: :Angew Chem Int Ed Engl
Главные авторы: Paul, Rakesh, Dutta, Debasish, Paul, Raj, Dash, Jyotirmayee
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687225/
https://ncbi.nlm.nih.gov/pubmed/32329147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202003461
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