Synthesis of Stable NAD(+) Mimics as Inhibitors for the Legionella pneumophila Phosphoribosyl Ubiquitylating Enzyme SdeC

Stable NAD(+) analogues carrying single atom substitutions in either the furanose ring or the nicotinamide part have proven their value as inhibitors for NAD(+)‐consuming enzymes. To investigate the potential of such compounds to inhibit the adenosine diphosphate ribosyl (ADPr) transferase activity...

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Detalles Bibliográficos
Publicado en:Chembiochem
Main Authors: Madern, Jerre M., Kim, Robbert Q., Misra, Mohit, Dikic, Ivan, Zhang, Yong, Ovaa, Huib, Codée, Jeroen D. C., Filippov, Dmitri V., van der Heden van Noort, Gerbrand J.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
Assuntos:
Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687180/
https://ncbi.nlm.nih.gov/pubmed/32421893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000230
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