Macroscopic fluorescence-lifetime imaging of NADH and protoporphyrin IX improves the detection and grading of 5-aminolevulinic acid-stained brain tumors

Maximal safe tumor resection remains the key prognostic factor for improved prognosis in brain tumor patients. Despite 5-aminolevulinic acid-based fluorescence guidance the neurosurgeon is, however, not able to visualize most low-grade gliomas (LGG) and infiltration zone of high-grade gliomas (HGG)....

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Published in:Sci Rep
Main Authors: Erkkilä, Mikael T., Reichert, David, Gesperger, Johanna, Kiesel, Barbara, Roetzer, Thomas, Mercea, Petra A., Drexler, Wolfgang, Unterhuber, Angelika, Leitgeb, Rainer A., Woehrer, Adelheid, Rueck, Angelika, Andreana, Marco, Widhalm, Georg
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686506/
https://ncbi.nlm.nih.gov/pubmed/33235233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77268-8
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