Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension

OBJECTIVES: To identify predictors of portal hypertension, liver transplantation, and death in North American youth with alpha-1-antitrypsin (AAT) deficiency, and compare with AAT deficiency patients elsewhere. STUDY DESIGN: The Childhood Liver Disease Research Network Longitudinal Observational Stu...

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Pubblicato in:J Pediatr
Autori principali: Teckman, Jeffrey, Rosenthal, Philip, Hawthorne, Kieran, Spino, Cathie, Bass, Lee M., Murray, Karen F., Kerkar, Nanda, Magee, John C., Karpen, Saul, Heubi, James E., Molleston, Jean P., Squires, Robert H., Kamath, Binita M., Guthery, Stephen L., Loomes, Kathleen M., Sherker, Averell H., Sokol, Ronald J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686087/
https://ncbi.nlm.nih.gov/pubmed/32663593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2020.07.031
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