Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells

The alteration of amyloid precursor protein (APP) proteolysis is a hallmark of Alzheimer's disease (AD). Recent studies have described noncanonical pathways of APP processing that seem partly executed by lysosomal enzymes. Our laboratory's in vitro human SK-N-MC model has shown that oxidat...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Llorente, Patricia, Martins, Soraia, Sastre, Isabel, Aldudo, Jesús, Recuero, María, Adjaye, James, Bullido, Maria J.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685830/
https://ncbi.nlm.nih.gov/pubmed/33282112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5917187
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