Inhibition of IRF5 hyperactivation protects from lupus onset and severity

The transcription factor IFN regulatory factor 5 (IRF5) is a central mediator of innate and adaptive immunity. Genetic variations within IRF5 are associated with a risk of systemic lupus erythematosus (SLE), and mice lacking Irf5 are protected from lupus onset and severity, but how IRF5 functions in...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Song, Su, De, Saurav, Nelson, Victoria, Chopra, Samin, LaPan, Margaret, Kampta, Kyle, Sun, Shan, He, Mingzhu, Thompson, Cherrie D., Li, Dan, Shih, Tiffany, Tan, Natalie, Al-Abed, Yousef, Capitle, Eugenio, Aranow, Cynthia, Mackay, Meggan, Clapp, William L., Barnes, Betsy J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685739/
https://ncbi.nlm.nih.gov/pubmed/32897883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120288
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