Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating

Dysregulation of habit formation has been recently proposed as pivotal to eating disorders. Here, we report that a subset of patients suffering from restrictive anorexia nervosa have enhanced habit formation compared with healthy controls. Habit formation is modulated by striatal cholinergic interne...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Favier, Mathieu, Janickova, Helena, Justo, Damian, Kljakic, Ornela, Runtz, Léonie, Natsheh, Joman Y., Pascoal, Tharick A., Germann, Jurgen, Gallino, Daniel, Kang, Jun-II, Meng, Xiang Qi, Antinora, Christina, Raulic, Sanda, Jacobsen, Jacob P.R., Moquin, Luc, Vigneault, Erika, Gratton, Alain, Caron, Marc G., Duriez, Philibert, Brandon, Mark P., Neto, Pedro Rosa, Chakravarty, M. Mallar, Herzallah, Mohammad M., Gorwood, Philip, Prado, Marco A.M., Prado, Vania F., El Mestikawy, Salah
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685731/
https://ncbi.nlm.nih.gov/pubmed/33164988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138532
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