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Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating

Dysregulation of habit formation has been recently proposed as pivotal to eating disorders. Here, we report that a subset of patients suffering from restrictive anorexia nervosa have enhanced habit formation compared with healthy controls. Habit formation is modulated by striatal cholinergic interne...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Favier, Mathieu, Janickova, Helena, Justo, Damian, Kljakic, Ornela, Runtz, Léonie, Natsheh, Joman Y., Pascoal, Tharick A., Germann, Jurgen, Gallino, Daniel, Kang, Jun-II, Meng, Xiang Qi, Antinora, Christina, Raulic, Sanda, Jacobsen, Jacob P.R., Moquin, Luc, Vigneault, Erika, Gratton, Alain, Caron, Marc G., Duriez, Philibert, Brandon, Mark P., Neto, Pedro Rosa, Chakravarty, M. Mallar, Herzallah, Mohammad M., Gorwood, Philip, Prado, Marco A.M., Prado, Vania F., El Mestikawy, Salah
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685731/
https://ncbi.nlm.nih.gov/pubmed/33164988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138532
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