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Regional Delivery of Chimeric Antigen Receptor–Engineered T Cells Effectively Targets HER2(+) Breast Cancer Metastasis to the Brain
PURPOSE: Metastasis to the brain from breast cancer remains a significant clinical challenge, and may be targeted with CAR-based immunotherapy. CAR design optimization for solid tumors is crucial due to the absence of truly restricted antigen expression and potential safety concerns with “on-target...
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| Опубликовано в: : | Clin Cancer Res |
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| Главные авторы: | , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7685198/ https://ncbi.nlm.nih.gov/pubmed/29061641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2041 |
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