Regional Delivery of Chimeric Antigen Receptor–Engineered T Cells Effectively Targets HER2(+) Breast Cancer Metastasis to the Brain

PURPOSE: Metastasis to the brain from breast cancer remains a significant clinical challenge, and may be targeted with CAR-based immunotherapy. CAR design optimization for solid tumors is crucial due to the absence of truly restricted antigen expression and potential safety concerns with “on-target...

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Udgivet i:Clin Cancer Res
Main Authors: Priceman, Saul J., Tilakawardane, Dileshni, Jeang, Brook, Aguilar, Brenda, Murad, John P., Park, Anthony K., Chang, Wen-Chung, Ostberg, Julie R., Neman, Josh, Jandial, Rahul, Portnow, Jana, Forman, Stephen J., Brown, Christine E.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685198/
https://ncbi.nlm.nih.gov/pubmed/29061641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2041
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