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HIV and opiates dysregulate K(+)-Cl(−) cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV. While neurons themselves are not infected, they incur sublethal damage and GABAergic d...
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| Publicado en: | Neurobiol Dis |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7685173/ https://ncbi.nlm.nih.gov/pubmed/32344154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.104878 |
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