Antimicrobial peptide AR‐23 derivatives with high endosomal disrupting ability enhance poly(l‐lysine)‐mediated gene transfer

BACKGROUND: pH‐sensitive peptides are a relatively new strategy for conquering the poor endosomal release of cationic polymer‐mediated transfection. Modification of antimicrobial peptides by exchanging positively‐charged residues with negatively‐charged glutamic acid residues (Glu) greatly improves...

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Vydáno v:J Gene Med
Hlavní autoři: Zhang, Shi‐Kun, Gong, Lin, Zhang, Xue, Yun, Zhi‐Min, Li, Su‐Bo, Gao, Hong‐Wei, Dai, Cong‐Jie, Yuan, Jian‐Jun, Chen, Jing‐Ming, Gong, Feng, Tan, Ying‐Xia, Ji, Shou‐Ping
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685122/
https://ncbi.nlm.nih.gov/pubmed/32776410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.3259
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