Wrinkle in the plan: miR-34a-5p impacts chemokine signaling by modulating CXCL10/CXCL11/CXCR3-axis in CD4(+), CD8(+) T cells, and M1 macrophages

BACKGROUND: In 2016 the first-in-human phase I study of a miRNA-based cancer therapy with a liposomal mimic of microRNA-34a-5p (miR-34a-5p) was closed due to five immune related serious adverse events (SAEs) resulting in four patient deaths. For future applications of miRNA mimics in cancer therapy...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Hart, Martin, Nickl, Laura, Walch-Rueckheim, Barbara, Krammes, Lena, Rheinheimer, Stefanie, Diener, Caroline, Taenzer, Tanja, Kehl, Tim, Sester, Martina, Lenhof, Hans-Peter, Keller, Andreas, Meese, Eckart
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Basic Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7684812/
https://ncbi.nlm.nih.gov/pubmed/33229509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001617
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