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Modeling α-Synucleinopathy in Organotypic Brain Slice Culture with Preformed α-Synuclein Amyloid Fibrils

BACKGROUND: Synucleinopathy is a group of neurodegenerative disorders characterized by neurodegeneration and accumulation of alpha-synuclein (α-syn) aggregates in various brain regions. The detailed mechanism of α-syn-caused neurotoxicity remains obscure, which is partly due to the lack of a suitabl...

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Bibliografski detalji
Izdano u:J Parkinsons Dis
Glavni autori: Roux, Amandine, Wang, Xinhe, Becker, Katelyn, Ma, Jiyan
Format: Artigo
Jezik:Inglês
Izdano: IOS Press 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7683096/
https://ncbi.nlm.nih.gov/pubmed/32716318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JPD-202026
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