Talin-activated vinculin interacts with branched actin networks to initiate bundles

Vinculin plays a fundamental role in integrin-mediated cell adhesion. Activated by talin, it interacts with diverse adhesome components, enabling mechanical coupling between the actin cytoskeleton and the extracellular matrix. Here we studied the interactions of activated full-length vinculin with a...

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Bibliographic Details
Published in:eLife
Main Authors: Boujemaa-Paterski, Rajaa, Martins, Bruno, Eibauer, Matthias, Beales, Charlie T, Geiger, Benjamin, Medalia, Ohad
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682986/
https://ncbi.nlm.nih.gov/pubmed/33185186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53990
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