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Redox-mediated regulation of an evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain
A methionine-rich low complexity (LC) domain is found within a C-terminal region of the TDP43 RNA-binding protein. Self-association of this domain leads to the formation of labile cross-β polymers and liquid-like droplets. Treatment with H(2)O(2) caused phenomena of methionine oxidation and droplet...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
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| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7682574/ https://ncbi.nlm.nih.gov/pubmed/33144500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012216117 |
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