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Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of its Methionine-Rich Low Complexity Domain
Yeast ataxin-2, also known as Pbp1, senses the activity state of mitochondria in order to regulate TORC1. A domain of Pbp1 required to adapt cells to mitochondrial activity is of low sequence complexity. The low complexity (LC) domain of Pbp1 forms labile, cross-β polymers that facilitate phase tran...
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| Publié dans: | Cell |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6752730/ https://ncbi.nlm.nih.gov/pubmed/30982603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.02.044 |
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