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Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of its Methionine-Rich Low Complexity Domain

Yeast ataxin-2, also known as Pbp1, senses the activity state of mitochondria in order to regulate TORC1. A domain of Pbp1 required to adapt cells to mitochondrial activity is of low sequence complexity. The low complexity (LC) domain of Pbp1 forms labile, cross-β polymers that facilitate phase tran...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Cell
मुख्य लेखकों: Kato, Masato, Yang, Yu-San, Sutter, Benjamin M., Wang, Yun, McKnight, Steven L., Tu, Benjamin P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752730/
https://ncbi.nlm.nih.gov/pubmed/30982603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.02.044
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