A missense variant in SLC39A8 confers risk for Crohn’s disease by disrupting manganese homeostasis and intestinal barrier integrity

Common genetic variants interact with environmental factors to impact risk of heritable diseases. A notable example of this is a single-nucleotide variant in the Solute Carrier Family 39 Member 8 (SLC39A8)geneencoding the missense variant A391T, which is associated with a variety of traits ranging f...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Nakata, Toru, Creasey, Elizabeth A., Kadoki, Motohiko, Lin, Helen, Selig, Martin K., Yao, Junmei, Lefkovith, Ariel, Daly, Mark J., Graham, Daniel B., Xavier, Ramnik J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682327/
https://ncbi.nlm.nih.gov/pubmed/33139556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014742117
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