The expression of the acarbose biosynthesis gene cluster in Actinoplanes sp. SE50/110 is dependent on the growth phase

BACKGROUND: Actinoplanes sp. SE50/110 is the natural producer of the diabetes mellitus drug acarbose, which is highly produced during the growth phase and ceases during the stationary phase. In previous works, the growth-dependency of acarbose formation was assumed to be caused by a decreasing trans...

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Publicat a:BMC Genomics
Autors principals: Droste, Julian, Ortseifen, Vera, Schaffert, Lena, Persicke, Marcus, Schneiker-Bekel, Susanne, Pühler, Alfred, Kalinowski, Jörn
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682106/
https://ncbi.nlm.nih.gov/pubmed/33225887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-07194-6
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