Absence of the highly expressed small carbohydrate-binding protein Cgt improves the acarbose formation in Actinoplanes sp. SE50/110

Actinoplanes sp. SE50/110 (ATCC 31044) is the wild type of industrial producer strains of acarbose. Acarbose has been used since the early 1990s as an inhibitor of intestinal human α-glucosidases in the medical treatment of type II diabetes mellitus. The small secreted protein Cgt, which consists of...

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Vydáno v:Appl Microbiol Biotechnol
Hlavní autoři: Schaffert, Lena, Schneiker-Bekel, Susanne, Gierhake, Jessica, Droste, Julian, Persicke, Marcus, Rosen, Winfried, Pühler, Alfred, Kalinowski, Jörn
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2020
Témata:
Applied Genetics and Molecular Biotechnology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275007/
https://ncbi.nlm.nih.gov/pubmed/32346757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-020-10584-1
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