FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16(INK4a) increase

Neurodegenerative diseases (ND) have been linked to the critical process in aging—cellular senescence. However, the temporal dynamics of cellular senescence in ND conditions is unresolved. Here, we show senescence features develop in human Huntington's disease (HD) neural stem cells (NSCs) and...

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發表在:Aging Cell
Main Authors: Voisin, Jessica, Farina, Francesca, Naphade, Swati, Fontaine, Morgane, Tshilenge, Kizito‐Tshitoko, Galicia Aguirre, Carlos, Lopez‐Ramirez, Alejandro, Dancourt, Julia, Ginisty, Aurélie, Sasidharan Nair, Satish, Lakshika Madushani, Kuruwitage, Zhang, Ningzhe, Lejeune, François‐Xavier, Verny, Marc, Campisi, Judith, Ellerby, Lisa M., Neri, Christian
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2020
主題:
Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681055/
https://ncbi.nlm.nih.gov/pubmed/33156570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13226
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