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Uncoupling the hydrolysis of lipid-linked oligosaccharide from the oligosaccharyl transfer reaction by point mutations in yeast oligosaccharyltransferase

Oligosaccharyltransferase (OST) is responsible for the first step in the N-linked glycosylation, transferring an oligosaccharide chain onto asparagine residues to create glycoproteins. In the absence of an acceptor asparagine, OST hydrolyzes the oligosaccharide donor, releasing free N-glycans (FNGs)...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Yamasaki, Takahiro, Kohda, Daisuke
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681024/
https://ncbi.nlm.nih.gov/pubmed/32938717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015013
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