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Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease

Dysregulated Wnt signaling is linked to major neurodegenerative diseases, including Alzheimer disease (AD). In mouse models of AD, activation of the canonical Wnt signaling pathway improves learning/memory, but the mechanism for this remains unclear. The decline in brain function in AD patients corr...

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Bibliografiske detaljer
Udgivet i:J Neurochem
Main Authors: Cisternas, Pedro, Zolezzi, Juan M., Martinez, Milka, Torres, Viviana. I., Wong, G. William, Inestrosa, Nibaldo C.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680578/
https://ncbi.nlm.nih.gov/pubmed/30300917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14608
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