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Brain Astrocytes and microglia express functional MR1 molecules that present microbial antigens to mucosal-associated invariant T (MAIT) cells

It is unknown whether brain astrocytes and microglia have the capacity to present microbial antigens via the innate immune MR1/MAIT cell axis. We have detected MAIT cells in the normal mouse brain and found that both astrocytes and microglia are MR1(+). When we stimulated brain astrocytes and microg...

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Pubblicato in:J Neuroimmunol
Autori principali: Priya, Raj, Brutkiewicz, Randy R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680413/
https://ncbi.nlm.nih.gov/pubmed/33096293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2020.577428
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