Intestinal Epithelial TBK1 Prevents Differentiation of T-helper 17 Cells and Tumorigenesis in Mice

BACKGROUND & AIMS: Intestinal epithelial cells (IECs) regulate intestinal immune cells, particularly development of T-helper 17 (Th17) cells. Deregulation of this process leads to intestinal inflammation and tumorigenesis, via unknown mechanisms. TANK-binding kinase 1 (TBK1) is expressed by IECs...

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Publicado no:Gastroenterology
Main Authors: Yang, Jin-Young, Jie, Zuliang, Mathews, Amber, Zhou, Xiaofei, Li, Yanchuan, Gu, Meidi, Xie, Xiaoping, Ko, Chun-Jung, Cheng, Xuhong, Qi, Yuan, Estrella, Jeannelyn S., Wang, Jing, Sun, Shao-Cong
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680348/
https://ncbi.nlm.nih.gov/pubmed/32745468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.07.047
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