TBKBP1 and TBK1 form a growth factor signaling axis mediating immunosuppression and tumorigenesis

The kinase TBK1 responds to microbial stimuli and mediates type I interferon (IFN-I) induction. We show that TBK1 is also a central mediator of growth factor signaling; this function relies on a specific adaptor, TBK-binding protein 1 (TBKBP1). TBKBP1 recruits TBK1 to PKCθ via a scaffold protein, Ca...

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Udgivet i:Nat Cell Biol
Main Authors: Zhu, Lele, Li, Yanchuan, Xie, Xiaoping, Zhou, Xiaofei, Gu, Meidi, Jie, Zuliang, Ko, Chun-Jung, Gao, Tianxiao, Hernandez, Blanca E, Cheng, Xuhong, Sun, Shao-Cong
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901116/
https://ncbi.nlm.nih.gov/pubmed/31792381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0429-8
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