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Consensus mutagenesis approach improves the thermal stability of system x(c) (−) transporter, xCT, and enables cryo‐EM analyses
System x(c) (−) is an amino acid antiporter that imports L‐cystine into cells and exports intracellular L‐glutamate, at a 1:1 ratio. As L‐cystine is an essential precursor for glutathione synthesis, system x(c) (−) supports tumor cell growth through glutathione‐based oxidative stress resistance and...
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| Pubblicato in: | Protein Sci |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley & Sons, Inc.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7679960/ https://ncbi.nlm.nih.gov/pubmed/33016372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3966 |
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