Long-term effects of empagliflozin on excitation-contraction-coupling in human induced pluripotent stem cell cardiomyocytes

ABSTRACT: The SGLT2 inhibitor empagliflozin improved cardiovascular outcomes in patients with diabetes. As the cardiac mechanisms remain elusive, we investigated the long-term effects (up to 2 months) of empagliflozin on excitation-contraction (EC)-coupling in human cardiomyocytes derived from induc...

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Bibliografiske detaljer
Udgivet i:J Mol Med (Berl)
Main Authors: Pabel, Steffen, Reetz, Florian, Dybkova, Nataliya, Shomroni, Orr, Salinas, Gabriela, Mustroph, Julian, Hammer, Karin P., Hasenfuss, Gerd, Hamdani, Nazha, Maier, Lars S., Streckfuss-Bömeke, Katrin, Sossalla, Samuel
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679329/
https://ncbi.nlm.nih.gov/pubmed/33034709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-020-01989-6
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