Inhibition of Na(V)1.8 prevents atrial arrhythmogenesis in human and mice

Pharmacologic approaches for the treatment of atrial arrhythmias are limited due to side effects and low efficacy. Thus, the identification of new antiarrhythmic targets is of clinical interest. Recent genome studies suggested an involvement of SCN10A sodium channels (Na(V)1.8) in atrial electrophys...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Basic Res Cardiol
Prif Awduron: Pabel, Steffen, Ahmad, Shakil, Tirilomis, Petros, Stehle, Thea, Mustroph, Julian, Knierim, Maria, Dybkova, Nataliya, Bengel, Philipp, Holzamer, Andreas, Hilker, Michael, Streckfuss-Bömeke, Katrin, Hasenfuss, Gerd, Maier, Lars S., Sossalla, Samuel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2020
Pynciau:
Original Contribution
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033079/
https://ncbi.nlm.nih.gov/pubmed/32078054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-020-0780-8
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