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Docking-based identification of small-molecule binding sites at protein-protein interfaces

Protein-protein interactions play an essential role in many biological processes, and their perturbation is a major cause of disease. The use of small molecules to modulate them is attracting increased attention, but protein interfaces generally do not have clear cavities for binding small compounds...

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Detalles Bibliográficos
Publicado en:Comput Struct Biotechnol J
Autores principales: Rosell, Mireia, Fernández-Recio, Juan
Formato: Artigo
Lenguaje:Inglês
Publicado: Research Network of Computational and Structural Biotechnology 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679229/
https://ncbi.nlm.nih.gov/pubmed/33250973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.11.029
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