Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles

Although DNA methylation is the best characterized epigenetic mark, the mechanism by which it is targeted to specific regions in the genome remains unclear. Recent studies have revealed that local DNA methylation profiles might be dictated by cis-regulatory DNA sequences that mainly operate via DNA-...

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Foilsithe in:PLoS Genet
Main Authors: Martin-Trujillo, Alejandro, Patel, Nihir, Richter, Felix, Jadhav, Bharati, Garg, Paras, Morton, Sarah U., McKean, David M., DePalma, Steven R., Goldmuntz, Elizabeth, Gruber, Dorota, Kim, Richard, Newburger, Jane W., Porter, George A., Giardini, Alessandro, Bernstein, Daniel, Tristani-Firouzi, Martin, Seidman, Jonathan G., Seidman, Christine E., Chung, Wendy K., Gelb, Bruce D., Sharp, Andrew J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2020
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679001/
https://ncbi.nlm.nih.gov/pubmed/33216750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009189
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