Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles

Although DNA methylation is the best characterized epigenetic mark, the mechanism by which it is targeted to specific regions in the genome remains unclear. Recent studies have revealed that local DNA methylation profiles might be dictated by cis-regulatory DNA sequences that mainly operate via DNA-...

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Publicat a:PLoS Genet
Autors principals: Martin-Trujillo, Alejandro, Patel, Nihir, Richter, Felix, Jadhav, Bharati, Garg, Paras, Morton, Sarah U., McKean, David M., DePalma, Steven R., Goldmuntz, Elizabeth, Gruber, Dorota, Kim, Richard, Newburger, Jane W., Porter, George A., Giardini, Alessandro, Bernstein, Daniel, Tristani-Firouzi, Martin, Seidman, Jonathan G., Seidman, Christine E., Chung, Wendy K., Gelb, Bruce D., Sharp, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679001/
https://ncbi.nlm.nih.gov/pubmed/33216750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009189
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