Evodiamine suppresses non-small cell lung cancer by elevating CD8(+) T cells and downregulating the MUC1-C/PD-L1 axis

BACKGROUND: Accumulating evidence showed that regulating tumor microenvironment plays a vital role in improving antitumor efficiency. Programmed Death Ligand 1 (PD-L1) is expressed in many cancer cell types, while its binding partner Programmed Death 1 (PD1) is expressed in activated T cells and ant...

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Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Jiang, Ze-Bo, Huang, Ju-Min, Xie, Ya-Jia, Zhang, Yi- Zhong, Chang, Chan, Lai, Huan-Ling, Wang, Wenjun, Yao, Xiao-Jun, Fan, Xing-Xing, Wu, Qi-Biao, Xie, Chun, Wang, Mei-Fang, Leung, Elaine Lai-Han
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677782/
https://ncbi.nlm.nih.gov/pubmed/33208183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01741-5
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