Clinical Characteristics and Prognosis of Gastric Cancer Patients with BRCA 1/2 Germline Mutations: Report of Ten Cases and a Literature Review

BACKGROUND: The prognosis of gastric cancer (GC) is poor with a median overall survival (OS) of less than 12 months in advanced-stage disease. The search for distinct genetic subgroups of GC patients and predictive biomarkers is ongoing. While BRCA1 or BRCA2 germline mutations (gBRCAm) have potentia...

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Dettagli Bibliografici
Pubblicato in:Onco Targets Ther
Autori principali: Halpern, Naama, Grinshpun, Albert, Boursi, Ben, Golan, Talia, Margalit, Ofer, Aderka, Dan, Friedman, Eitan, Laitman, Yael, Hubert, Ayala, Kadouri, Luna, Hamburger, Tamar, Barnes-Kedar, Inbal, Levi, Zohar, Ben-Aharon, Irit, Brenner, Baruch, Goldberg, Yael, Peretz, Tamar, Shacham-Shmueli, Einat
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677647/
https://ncbi.nlm.nih.gov/pubmed/33235458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S276814
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